health.data DRIVEN Lab: Publications

2024

Thresholding approaches for estimating paraspinal muscle fat infiltration using T1- and T2-weighted MRI: Comparative analysis using water-fat MRI.

Jessica Ornowski; Lucas Dziesinski; Madeline Hess; Roland Krug; Maryse Fortin; Abel Torres-Espin; Sharmila Majumdar; Valentina Pedoia; Noah B Bonnheim; Jeannie F Bailey . JOR spine

2023

Data-driven distillation and precision prognosis in traumatic brain injury with interpretable machine learning.

Andrew Tritt; John K Yue; Adam R Ferguson; Abel Torres Espin; Lindsay D Nelson; Esther L Yuh; Amy J Markowitz; Geoffrey T Manley; Kristofer E Bouchard . Scientific reports

Correction: Expert-augmented automated machine learning optimizes hemodynamic predictors of spinal cord injury outcome.

Austin Chou; Abel Torres-Espin; Nikos Kyritsis; J Russell Huie; Sarah Khatry; Jeremy Funk; Jennifer Hay; Andrew Lofgreen; Rajiv Shah; Chandler McCann; Lisa U Pascual; Edilberto Amorim; Philip R Weinstein; Geoffrey T Manley; Sanjay S Dhall; Jonathan Z Pan; Jacqueline C Bresnahan; Michael S Beattie; William D Whetstone; Adam R Ferguson . PloS one

Safety and comparative efficacy of initiating low-molecular-weight heparin within 24 hours of injury or surgery for venous thromboembolism prophylaxis in patients with spinal cord injury: a prospective TRACK-SCI registry study.

Austin Lui; Christine Park; Timothy Chryssikos; Hannah Radabaugh; Arati Patel; Alexander A Aabedi; Adam R Ferguson; Abel Torres Espin; Praveen V Mummaneni; Sanjay S Dhall; Xuan Duong-Fernandez; Rajiv Saigal; Austin Chou; Jonathan Pan; Vineeta Singh; Debra D Hemmerle; Nikos Kyritsis; Jason F Talbott; Lisa U Pascual; J Russell Huie; William D Whetstone; Jacqueline C Bresnahan; Michael S Beattie; Philip R Weinstein; Geoffrey T Manley; Anthony M DiGiorgio . Neurosurgical focus

Improving rigor and reproducibility in western blot experiments with the blotRig analysis software.

Cleopa Omondi; Austin Chou; Kenneth A Fond; Kazuhito Morioka; Nadine R Joseph; Jeffrey A Sacramento; Emma Iorio; Abel Torres-Espin; Hannah L Radabaugh; Jacob A Davis; Jason H Gumbel; J Russell Huie; Adam R Ferguson . bioRxiv : the preprint server for biology

Multi-domain biopsychosocial postoperative recovery trajectories associate with patient outcomes following lumbar fusion.

Ryan T Halvorson; Abel Torres-Espin; Matthew Callahan; Bobby Tay; Conor O'Neill; Sigurd Berven; Jeffrey C Lotz; Jeannie F Bailey . European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Hypotension requiring vasopressor treatment and increased cardiac complications in elderly spinal cord injury patients: a prospective TRACK-SCI registry study.

Nitin Agarwal; Jacob Blitstein; Austin Lui; Abel Torres-Espin; Chalisar Vasnarungruengkul; John Burke; Praveen V Mummaneni; Sanjay S Dhall; Philip R Weinstein; Xuan Duong-Fernandez; Austin Chou; Jonathan Pan; Vineeta Singh; Adam R Ferguson; Debra D Hemmerle; Nikos Kyritsis; Jason F Talbott; William D Whetstone; Jacqueline C Bresnahan; Michael S Beattie; Geoffrey T Manley; Anthony DiGiorgio . Journal of neurosurgery. Spine

#OrthoTwitter: Relationship Between Author Twitter Utilization and Academic Impact in Orthopaedic Surgery.

Ryan T Halvorson; Sachin Allahabadi; Nicolas Cevallos; Aidan J Foley; Kelsey Collins; Abel Torres Espin; Brian T Feeley; Nirav K Pandya; Jeannie F Bailey . Cureus

Combined space stressors induce independent behavioral deficits predicted by early peripheral blood monocytes.

Kira D A Rienecker; Katherine Grue; Maria Serena Paladini; Elma S Frias; Valentina Frattini; Mia C Borlongan; Austin Chou; Abel Torres-Espin; Karen Krukowski; Adam R Ferguson; Susanna Rosi . Scientific reports

Empowering Data Sharing and Analytics through the Open Data Commons for Traumatic Brain Injury Research.

Austin Chou; Abel Torres-Espín; J Russell Huie; Karen Krukowski; Sangmi Lee; Amber Nolan; Caroline Guglielmetti; Bridget E Hawkins; Myriam M Chaumeil; Geoffrey T Manley; Michael S Beattie; Jacqueline C Bresnahan; Maryann E Martone; Jeffrey S Grethe; Susanna Rosi; Adam R Ferguson . Neurotrauma reports

2022

A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice.

Aina Calls; Abel Torres-Espin; Marc Tormo; Laura Martínez-Escardó; Núria Bonet; Ferran Casals; Xavier Navarro; Víctor J Yuste; Esther Udina; Jordi Bruna . Annals of clinical and translational neurology

FAIR Data Reuse in Traumatic Brain Injury: Exploring Inflammation and Age as Moderators of Recovery in the TRACK-TBI Pilot.

J Russell Huie; Austin Chou; Abel Torres-Espin; Jessica L Nielson; Esther L Yuh; Raquel C Gardner; Ramon Diaz-Arrastia; Geoff T Manley; Adam R Ferguson . Frontiers in neurology

Harmonization-Information Trade-Offs for Sharing Individual Participant Data in Biomedicine.

Abel Torres-Espín; Adam R Ferguson . Harvard data science review

Traumatic brain injury: progress and challenges in prevention, clinical care, and research.

Andrew I R Maas; David K Menon; Geoffrey T Manley; Mathew Abrams; Cecilia Åkerlund; Nada Andelic; Marcel Aries; Tom Bashford; Michael J Bell; Yelena G Bodien; Benjamin L Brett; András Büki; Randall M Chesnut; Giuseppe Citerio; David Clark; Betony Clasby; D Jamie Cooper; Endre Czeiter; Marek Czosnyka; Kristen Dams-O'Connor; Véronique De Keyser; Ramon Diaz-Arrastia; Ari Ercole; Thomas A van Essen; Éanna Falvey; Adam R Ferguson; Anthony Figaji; Melinda Fitzgerald; Brandon Foreman; Dashiell Gantner; Guoyi Gao; Joseph Giacino; Benjamin Gravesteijn; Fabian Guiza; Deepak Gupta; Mark Gurnell; Juanita A Haagsma; Flora M Hammond; Gregory Hawryluk; Peter Hutchinson; Mathieu van der Jagt; Sonia Jain; Swati Jain; Ji-Yao Jiang; Hope Kent; Angelos Kolias; Erwin J O Kompanje; Fiona Lecky; Hester F Lingsma; Marc Maegele; Marek Majdan; Amy Markowitz; Michael McCrea; Geert Meyfroidt; Ana Mikolić; Stefania Mondello; Pratik Mukherjee; David Nelson; Lindsay D Nelson; Virginia Newcombe; David Okonkwo; Matej Orešič; Wilco Peul; Dana Pisică; Suzanne Polinder; Jennie Ponsford; Louis Puybasset; Rahul Raj; Chiara Robba; Cecilie Røe; Jonathan Rosand; Peter Schueler; David J Sharp; Peter Smielewski; Murray B Stein; Nicole von Steinbüchel; William Stewart; Ewout W Steyerberg; Nino Stocchetti; Nancy Temkin; Olli Tenovuo; Alice Theadom; Ilias Thomas; Abel Torres Espin; Alexis F Turgeon; Andreas Unterberg; Dominique Van Praag; Ernest van Veen; Jan Verheyden; Thijs Vande Vyvere; Kevin K W Wang; Eveline J A Wiegers; W Huw Williams; Lindsay Wilson; Stephen R Wisniewski; Alexander Younsi; John K Yue; Esther L Yuh; Frederick A Zeiler; Marina Zeldovich; Roger Zemek . The Lancet. Neurology

Excavating FAIR Data: the Case of the Multicenter Animal Spinal Cord Injury Study (MASCIS), Blood Pressure, and Neuro-Recovery.

Carlos A Almeida; Abel Torres-Espin; J Russell Huie; Dongming Sun; Linda J Noble-Haeusslein; Wise Young; Michael S Beattie; Jacqueline C Bresnahan; Jessica L Nielson; Adam R Ferguson . Neuroinformatics

Promoting FAIR Data Through Community-driven Agile Design: the Open Data Commons for Spinal Cord Injury (odc-sci.org).

Abel Torres-Espín; Carlos A Almeida; Austin Chou; J Russell Huie; Michael Chiu; Romana Vavrek; Jeff Sacramento; Michael B Orr; John C Gensel; Jeffery S Grethe; Maryann E Martone; Karim Fouad; Adam R Ferguson . Neuroinformatics

Appendicular Fracture and Polytrauma Correlate with Outcome of Spinal Cord Injury: A Transforming Research and Clinical Knowledge in Spinal Cord Injury Study.

Theodore A Miclau; Abel Torres-Espin; Saam Morshed; Kazuhito Morioka; J Russell Huie; Ashraf N El Naga; Austin Chou; Lisa Pascual; Xuan Duong-Fernandez; Yu-Hung Kuo; Philip Weinstein; Sanjay S Dhall; Jacqueline C Bresnahan; Michael S Beattie; Anthony Digiorgio; Adam R Ferguson . Journal of neurotrauma

Using hierarchical unsupervised learning to integrate and reduce multi-level and multi-paraspinal muscle MRI data in relation to low back pain.

Abel Torres-Espin; Anastasia Keller; Gabriel T A Johnson; Aaron J Fields; Roland Krug; Adam R Ferguson; Alan R Hargens; Conor W O'Neill; Jeffrey C Lotz; Jeannie F Bailey . European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Unsupervised Machine Learning on Motion Capture Data Uncovers Movement Strategies in Low Back Pain.

Anastasia V Keller; Abel Torres-Espin; Thomas A Peterson; Jacqueline Booker; Conor O'Neill; Jeffrey C Lotz; Jeannie F Bailey; Adam R Ferguson; Robert P Matthew . Frontiers in bioengineering and biotechnology

Chondroitin sulfate proteoglycans prevent immune cell phenotypic conversion and inflammation resolution via TLR4 in rodent models of spinal cord injury.

Isaac Francos-Quijorna; Marina Sánchez-Petidier; Emily R Burnside; Smaranda R Badea; Abel Torres-Espin; Lucy Marshall; Fred de Winter; Joost Verhaagen; Victoria Moreno-Manzano; Elizabeth J Bradbury . Nature communications

Expert-augmented automated machine learning optimizes hemodynamic predictors of spinal cord injury outcome.

Decision tree-based machine learning analysis of intraoperative vasopressor use to optimize neurological improvement in acute spinal cord injury.

Nitin Agarwal; Alexander A Aabedi; Abel Torres-Espin; Austin Chou; Thomas A Wozny; Praveen V Mummaneni; John F Burke; Adam R Ferguson; Nikos Kyritsis; Sanjay S Dhall; Philip R Weinstein; Xuan Duong-Fernandez; Jonathan Pan; Vineeta Singh; Debra D Hemmerle; Jason F Talbott; William D Whetstone; Jacqueline C Bresnahan; Geoffrey T Manley; Michael S Beattie; Anthony M DiGiorgio . Neurosurgical focus

Effect of frailty on 6-month outcome after traumatic brain injury: a multicentre cohort study with external validation.

Stefania Galimberti; Francesca Graziano; Andrew I R Maas; Giulia Isernia; Fiona Lecky; Sonia Jain; Xiaoying Sun; Raquel C Gardner; Sabrina R Taylor; Amy J Markowitz; Geoffrey T Manley; Maria Grazia Valsecchi; Giuseppe Bellelli; Giuseppe Citerio . The Lancet. Neurology

Mixture Model Framework for Traumatic Brain Injury Prognosis Using Heterogeneous Clinical and Outcome Data.

Alan D Kaplan; Qi Cheng; K Aditya Mohan; Lindsay D Nelson; Sonia Jain; Harvey Levin; Abel Torres-Espin; Austin Chou; J Russell Huie; Adam R Ferguson; Michael McCrea; Joseph Giacino; Shivshankar Sundaram; Amy J Markowitz; Geoffrey T Manley . IEEE journal of biomedical and health informatics

Reproducible analysis of disease space via principal components using the novel R package syndRomics.

Abel Torres-Espín; Austin Chou; J Russell Huie; Nikos Kyritsis; Pavan S Upadhyayula; Adam R Ferguson . eLife

Quantifying the kinematic features of dexterous finger movements in nonhuman primates with markerless tracking.

Ryan North; Rachele Wurr; Ryan Macon; Christopher Mannion; John Hyde; Abel Torres-Espin; Ephron S Rosenzweig; Adam R Ferguson; Mark H Tuszynski; Michael S Beattie; Jacqueline C Bresnahan; Wilsaan M Joiner . Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2021

Beyond the lesion site: minocycline augments inflammation and anxiety-like behavior following SCI in rats through action on the gut microbiota.

Emma K A Schmidt; Pamela J F Raposo; Abel Torres-Espin; Keith K Fenrich; Karim Fouad . Journal of neuroinflammation

Topological network analysis of patient similarity for precision management of acute blood pressure in spinal cord injury.

Abel Torres-Espín; Jenny Haefeli; Reza Ehsanian; Dolores Torres; Carlos A Almeida; J Russell Huie; Austin Chou; Dmitriy Morozov; Nicole Sanderson; Benjamin Dirlikov; Catherine G Suen; Jessica L Nielson; Nikos Kyritsis; Debra D Hemmerle; Jason F Talbott; Geoffrey T Manley; Sanjay S Dhall; William D Whetstone; Jacqueline C Bresnahan; Michael S Beattie; Stephen L McKenna; Jonathan Z Pan; Adam R Ferguson . eLife

Automation of training and testing motor and related tasks in pre-clinical behavioural and rehabilitative neuroscience.

Kar Men Mah; Abel Torres-Espín; Ben W Hallworth; John L Bixby; Vance P Lemmon; Karim Fouad; Keith K Fenrich . Experimental neurology

Self-directed rehabilitation training intensity thresholds for efficient recovery of skilled forelimb function in rats with cervical spinal cord injury.

Keith K Fenrich; Ben W Hallworth; Romana Vavrek; Pamela J F Raposo; John E Misiaszek; David J Bennett; Karim Fouad; Abel Torres-Espin . Experimental neurology

Diagnostic blood RNA profiles for human acute spinal cord injury.

Nikos Kyritsis; Abel Torres-Espín; Patrick G Schupp; J Russell Huie; Austin Chou; Xuan Duong-Fernandez; Leigh H Thomas; Rachel E Tsolinas; Debra D Hemmerle; Lisa U Pascual; Vineeta Singh; Jonathan Z Pan; Jason F Talbott; William D Whetstone; John F Burke; Anthony M DiGiorgio; Philip R Weinstein; Geoffrey T Manley; Sanjay S Dhall; Adam R Ferguson; Michael C Oldham; Jacqueline C Bresnahan; Michael S Beattie . The Journal of experimental medicine

FAIR SCI Ahead: The Evolution of the Open Data Commons for Pre-Clinical Spinal Cord Injury Research.

Karim Fouad; John L Bixby; Alison Callahan; Jeffrey S Grethe; Lyn B Jakeman; Vance P Lemmon; David S K Magnuson; Maryann E Martone; Jessica L Nielson; Jan M Schwab; Carol Taylor-Burds; Wolfram Tetzlaff; Abel Torres-Espin; Adam R Ferguson . Journal of neurotrauma

Cisplatin-induced peripheral neuropathy is associated with neuronal senescence-like response.

Aina Calls; Abel Torres-Espin; Xavier Navarro; Victor J Yuste; Esther Udina; Jordi Bruna . Neuro-oncology

Transforming Research and Clinical Knowledge in Spinal Cord Injury (TRACK-SCI): an overview of initial enrollment and demographics.

Rachel E Tsolinas; John F Burke; Anthony M DiGiorgio; Leigh H Thomas; Xuan Duong-Fernandez; Mark H Harris; John K Yue; Ethan A Winkler; Catherine G Suen; Lisa U Pascual; Adam R Ferguson; J Russell Huie; Jonathan Z Pan; Debra D Hemmerle; Vineeta Singh; Abel Torres-Espin; Cleopa Omondi; Nikos Kyritsis; Jenny Haefeli; Philip R Weinstein; Carlos A de Almeida Neto; Yu-Hung Kuo; Derek Taggard; Jason F Talbott; William D Whetstone; Geoffrey T Manley; Jacqueline C Bresnahan; Michael S Beattie; Sanjay S Dhall . Neurosurgical focus

Injury volume extracted from MRI predicts neurologic outcome in acute spinal cord injury: A prospective TRACK-SCI pilot study.

Nikhil Mummaneni; John F Burke; Anthony M DiGiorgio; Leigh H Thomas; Xuan Duong-Fernandez; Mark Harris; Lisa U Pascual; Adam R Ferguson; J Russell Huie; Jonathan Z Pan; Debra D Hemmerle; Vineeta Singh; Abel Torres-Espin; Cleopa Omondi; Nikos Kyritsis; Phillip R Weinstein; William D Whetstone; Geoffrey T Manley; Jacqueline C Bresnahan; Michael S Beattie; Julien Cohen-Adad; Sanjay S Dhall; Jason F Talbott . Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

2020

Single-session cortical electrical stimulation enhances the efficacy of rehabilitative motor training after spinal cord injury in rats.

Nicholas J Batty; Abel Torres-Espín; Romana Vavrek; Pamela Raposo; Karim Fouad . Experimental neurology

Fecal transplant prevents gut dysbiosis and anxiety-like behaviour after spinal cord injury in rats.

Emma K A Schmidt; Abel Torres-Espin; Pamela J F Raposo; Karen L Madsen; Kristina A Kigerl; Phillip G Popovich; Keith K Fenrich; Karim Fouad . PloS one

2019

Rehabilitative Training in Animal Models of Spinal Cord Injury.

Abel Torres-Espín; Eric Beaudry; Keith Fenrich; Karim Fouad . Journal of neurotrauma

Eliciting inflammation enables successful rehabilitative training in chronic spinal cord injury.

Abel Torres-Espín; Juan Forero; Keith K Fenrich; Ana M Lucas-Osma; Aleksandra Krajacic; Emma Schmidt; Romana Vavrek; Pamela Raposo; David J Bennett; Phillip G Popovich; Karim Fouad . Brain : a journal of neurology

2018

Cyclosporine-immunosuppression does not affect survival of transplanted skin-derived precursor Schwann cells in the injured rat spinal cord.

Zacnicte May; Abel Torres-Espín; Ana M Lucas-Osma; Nicholas J Batty; Pamela Raposo; Keith K Fenrich; Morgan G Stykel; Tobias Führmann; Molly Shoichet; Jeff Biernaskie; Karim Fouad . Neuroscience letters

Following Spinal Cord Injury Transected Reticulospinal Tract Axons Develop New Collateral Inputs to Spinal Interneurons in Parallel with Locomotor Recovery.

Zacnicte May; Keith K Fenrich; Julia Dahlby; Nicholas J Batty; Abel Torres-Espín; Karim Fouad . Neural plasticity

A motorized pellet dispenser to deliver high intensity training of the single pellet reaching and grasping task in rats.

Abel Torres-Espín; Juan Forero; Emma K A Schmidt; Karim Fouad; Keith K Fenrich . Behavioural brain research

Effects of the Post-Spinal Cord Injury Microenvironment on the Differentiation Capacity of Human Neural Stem Cells Derived from Induced Pluripotent Stem Cells.

Clara López-Serrano; Abel Torres-Espín; Joaquim Hernández; Ana B Alvarez-Palomo; Jordi Requena; Xavier Gasull; Michael J Edel; Xavier Navarro . Cell transplantation

2016

Single pellet grasping following cervical spinal cord injury in adult rat using an automated full-time training robot.

Keith K Fenrich; Zacincte May; Abel Torres-Espín; Juan Forero; David J Bennett; Karim Fouad . Behavioural brain research

Beneficial effects of IL-37 after spinal cord injury in mice.

Marina Coll-Miró; Isaac Francos-Quijorna; Eva Santos-Nogueira; Abel Torres-Espin; Philip Bufler; Charles A Dinarello; Rubèn López-Vales . Proceedings of the National Academy of Sciences of the United States of America

2015

Immunosuppression of allogenic mesenchymal stem cells transplantation after spinal cord injury improves graft survival and beneficial outcomes.

Abel Torres-Espín; Elena Redondo-Castro; Joaquim Hernandez; Xavier Navarro . Journal of neurotrauma

Increased migration of olfactory ensheathing cells secreting the Nogo receptor ectodomain over inhibitory substrates and lesioned spinal cord.

Diego Reginensi; Patricia Carulla; Sara Nocentini; Oscar Seira; Xavier Serra-Picamal; Abel Torres-Espín; Andreu Matamoros-Angles; Rosalina Gavín; María Teresa Moreno-Flores; Francisco Wandosell; Josep Samitier; Xavier Trepat; Xavier Navarro; José Antonio del Río . Cellular and molecular life sciences : CMLS

Dithiocarb (N,N-diethyldithiocarbamate, DEDTC) decreases levels of biogenic monoamines in the adult mouse brain.

Elena Redondo-Castro; Rafael Romero; Abel Torres-Espín; Juana Utrera; Daniel Duque; Fèlix Junyent; Carme Auladell . Neuropathology and applied neurobiology

Activity dependent therapies modulate the spinal changes that motoneurons suffer after a peripheral nerve injury.

Ariadna Arbat-Plana; Abel Torres-Espín; Xavier Navarro; Esther Udina . Experimental neurology

Bone marrow mesenchymal stromal cells and olfactory ensheathing cells transplantation after spinal cord injury--a morphological and functional comparison in rats.

Abel Torres-Espín; Elena Redondo-Castro; Joaquim Hernández; Xavier Navarro . The European journal of neuroscience

2014

Gene expression changes in the injured spinal cord following transplantation of mesenchymal stem cells or olfactory ensheathing cells.

Abel Torres-Espín; Joaquim Hernández; Xavier Navarro . PloS one

2013

Neuroprotection and axonal regeneration after lumbar ventral root avulsion by re-implantation and mesenchymal stem cells transplant combined therapy.

Abel Torres-Espín; Dora Luz Corona-Quintanilla; Joaquim Forés; Ilary Allodi; Francisco González; Esther Udina; Xavier Navarro . Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Quantitative assessment of locomotion and interlimb coordination in rats after different spinal cord injuries.

Elena Redondo-Castro; Abel Torres-Espín; Guillermo García-Alías; Xavier Navarro . Journal of neuroscience methods

2012

Adult stem cell transplants for spinal cord injury repair: current state in preclinical research.

Joaquim Hernández; Abel Torres-Espín; Xavier Navarro . Current stem cell research & therapy

2011

Functional involvement of the lumbar spinal cord after contusion to T8 spinal segment of the rat.

Guillermo García-Alías; Abel Torres-Espín; Carolina Vallejo; Xavier Navarro . Restorative neurology and neuroscience

Publications